The Super Eagles of Nigeria will face Ghana, their West African arch-rivals, in the 2022 FIFA World Cup playoff.
The draw which was held in Douala, Cameroon will see Egypt square up against Senegal for a place in Qatar.
Cameroon, the host country of the 2022 Africa Cup of Nations (AFCON), will face Algeria to qualify for the tournament.
DR Congo will have Morocco to contend with, while Mali, the only team in the running yet to have appeared at the World Cup, will play Tunisia.
The matches will be played between March 24 and 29, 2022 with exact dates and kick-off times to be confirmed after CAF liaises with the involved football associations.
The five winners will represent Africa at the World Cup in Qatar.
The full pairing:
Egypt Vs Senegal
Cameroon Vs Algeria
Ghana Vs Nigeria
Dr Congo Vs Morocco
Mail Vs Tunisia